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Oxford Lipid Metabolism Group, Nuffield Department of Clinical Medicine, University of Oxford
Research at the Oxford Lipid Metabolism Group is targeted to further our understanding of the integration of whole body metabolic pathways of importance for obesity, type 2 diabetes mellitus and cardiovascular disease. By studying adipose tissue in vivo and in situ, we can investigate the specific role of the tissue for fatty acid metabolic pathways and endocrine functions (Frayn KN et al., 1997). Complimentary techniques to study adipose tissue such as microdialysis and blood flow measurement have enabled detailed analysis of functional aspects of metabolism. Key measurements have included estimations of the action of lipoprotein lipase which have allowed us to determine fatty acid mobilisation and deposition in response to different nutritional stimuli and physiological conditions . On-going projects can be summarised as follows: # Mechanisms of adipose tissue blood flow regulation # Specific dietary fatty acids and their effect on insulin secretion in humans # Mechanisms of hypertriglyceridaemia in response to high-carbohydrate diets # Fatty acid and adipose tissue metabolism in familial combined hyperlipidaemia # Oro-sensory stimulation by food intake and its effect on lipid metabolism # PPARgamma stimulation, adipose tissue gene expression and fatty acid metabolism # Consequences of heterogeneity in genes expressed in adipose tissue Some of these aspects are being intensively investigated through ‘Fatlink’ collaboration. References
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