In collaboration with Toulouse, we investigated the importance of alpha2- adrenoceptors in the control of adipose cell metabolism in various physiological and experimenal situations.

An alpha2-adrenoceptor-mediated blunting effect on exercise-induced lipolysis was demonstrated in healthy men. Collaborative studies are ongoing on the involvement of these receptors in the modifications of fat tissue metabolism brought up by high fat diet, hyperinsulinism and physical training. The interaction of the hypocaloric diet and alpha2 adrenoceptors  is also being studied.

Another group of collaborative studies with Toulouse is centered on the diet-induced modifications in gene expression and the study of interaction between plasma and adipose tissue fatty acid composition and mRNA expression. A study on adipose tissue gene expression in relation to thyroid diseases has been initiated.

Finally, a number of collaborative studies elucidating the role of ANP in the regulation of lipolysis during calorie restriction and during experimental hyperinsulinemia have been realized.

1: Hainer V, Kunesova M, Parizkova J, Stich V, Mikulova R, Slaba S. Respiratory quotient in obesity: its association with an ability to retain weight loss and with parental obesity. Sb Lek. 2000;101(1):99-104.

2: Hainer V, Stunkard AJ, Kunesova M, Parizkova J, Stich V, Allison DB. Intrapair resemblance in very low calorie diet-induced weight loss in female obese identical twins. Int J Obes Relat Metab Disord. 2000 Aug;24(8):1051-7.

3: Stich V, De Glisezinski I, Crampes F, Hejnova J, Cottet-Emard JM, Galitzky J, Lafontan M, Riviere D, Berlan M. Activation of alpha2-adrenergic receptors impairs exercise-induced lipolysis in SCAT of obese subjects. Am J Physiol Regul Integr Comp Physiol. 2000 Aug;279(2):R499-504.

4: Stich V, de Glisezinski I, Berlan M, Bulow J, Galitzky J, Harant I, Suljkovicova H, Lafontan M, Riviere D, Crampes F. Adipose tissue lipolysis is increased during a repeated bout of aerobic exercise. J Appl Physiol. 2000 Apr;88(4):1277-83.

5: Stich V, de Glisezinski I, Crampes F, Suljkovicova H, Galitzky J, Riviere D, Hejnova J, Lafontan M, Berlan M. Activation of antilipolytic alpha2-adrenergic receptors by epinephrine during exercise in human adipose tissue. Am J Physiol. 1999 Oct;277(4 Pt 2):R1076-83.