Analysis of adipokine concentrations in paediatric non-alcoholic fatty liver diseas
Fitzpatrick E, Dew TK, Quaglia A et al
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in children and the rising prevalence is closely associated with the rise in obesity. Adipokines, inflammatory mediators which arise from adipocytes or inflammatory cells infiltrating fatty tissue, are likely to be involved in the evolution of steatohepatitis from simple steatosis in nonalcoholic fatty liver disease.
Certain adipokines are differentially expressed with different severity of disease in paediatric NAFLD. Plasma monocyte chemoattractant protein 1 and resistin decrease with increasing severity of steatohepatitis. Plasma plasminogen activator 1 and monocyte chemoattractant protein 1 are increased in severe fibrotic NAFLD.
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