Replication of LIN28B SNP association with age of menarche in young Filipino women
Croteau-Chonka DC, Lange LA, Lee NR et al
Age of menarche, or the timing of first menses in girls, is a physiological trait that shows substantial genetic heritability. Earlier age of menarche is associated with increased childhood adiposity and with adult risk of obesity and cardiovascular disease.
We sought to further characterize the single nucleotide polymorphism (SNP) rs7759938 from the menarche locus LIN28B in 827 young Filipino women from the Cebu Longitudinal Health and Nutrition Survey (CLHNS).
These data confirm the strongest gene reported in Europeans (LIN28B) as a contributor to age of menarche in an Asian population.
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